we have studied pharmacodynamics of valepotriates through observing its effects on the times of spontaneous motion in mice, the sleep time of sodium pentobarbital ( superthreshold doses ), sleep rate of sodium pentobarbital ( subthreshold doses ), the number of writhes induced by acetic acid and seizures rate of metrazol . the experiment results proved that valepotriates could significantly decrease the times of spontaneous motion, prolong the sleep time of sodium pentobarbital ( superthreshold doses ), enhance the sleep rate of sodium pentobarbital ( subthreshold doses ), reduce the number of writhes induced by acetic acid and reduce the seizures rate of metrazol, so it showed high central inhibition effect, thus offer scientific foundation for its further exploitation and utilization 通過(guò)研究蜘蛛香中總纈草素對(duì)小鼠自發(fā)活動(dòng)的影響、對(duì)戊巴比妥鈉睡眠時(shí)間的影響、對(duì)戊巴比妥鈉閾下劑量的影響、對(duì)小鼠扭體反應(yīng)的影響、對(duì)戊四氮誘發(fā)驚厥的影響發(fā)現(xiàn):總顆草素能明顯抑制小鼠的自主活動(dòng),顯著延長(zhǎng)戊巴比妥鈉致小鼠睡眠時(shí)間,明顯提高閾下劑量戊巴比妥鈉小鼠入睡數(shù),對(duì)抗戊四氮誘發(fā)的小鼠驚厥,顯示出較好的中樞抑制作用,為蜘蛛香的進(jìn)一步研究開(kāi)發(fā)提供了科學(xué)依據(jù)。
we have studied pharmacodynamics of valepotriates through observing its effects on the times of spontaneous motion in mice, the sleep time of sodium pentobarbital ( superthreshold doses ), sleep rate of sodium pentobarbital ( subthreshold doses ), the number of writhes induced by acetic acid and seizures rate of metrazol . the experiment results proved that valepotriates could significantly decrease the times of spontaneous motion, prolong the sleep time of sodium pentobarbital ( superthreshold doses ), enhance the sleep rate of sodium pentobarbital ( subthreshold doses ), reduce the number of writhes induced by acetic acid and reduce the seizures rate of metrazol, so it showed high central inhibition effect, thus offer scientific foundation for its further exploitation and utilization 通過(guò)研究蜘蛛香中總纈草素對(duì)小鼠自發(fā)活動(dòng)的影響、對(duì)戊巴比妥鈉睡眠時(shí)間的影響、對(duì)戊巴比妥鈉閾下劑量的影響、對(duì)小鼠扭體反應(yīng)的影響、對(duì)戊四氮誘發(fā)驚厥的影響發(fā)現(xiàn):總顆草素能明顯抑制小鼠的自主活動(dòng),顯著延長(zhǎng)戊巴比妥鈉致小鼠睡眠時(shí)間,明顯提高閾下劑量戊巴比妥鈉小鼠入睡數(shù),對(duì)抗戊四氮誘發(fā)的小鼠驚厥,顯示出較好的中樞抑制作用,為蜘蛛香的進(jìn)一步研究開(kāi)發(fā)提供了科學(xué)依據(jù)。